Currently studied projects in the center

• Surface expression, function, and pharmacology of disease-associated mutations in human NMDA receptors – molecular diagnostics and drug development
• Targeted treatment for protein mutation and aggregation diseases – tauopathies, amyloidosis and cancer
• Targeted therapy for cells in stress – regulators of oncogenic, ribosomal and/or endoplasmatic stress response
• Gene expression therapeutics – epigenetic and transcriptional regulators
• Novel potent inhibitors of purine nucleoside phosphorylase for treatment of T-cell leukemia
• Senolytics – cytotoxic therapies for aging cells
• New human Constitutive androstane receptor (CAR, NR1I3) ligands for the treatment of metabolic diseases