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The Board of TACR approved 7 PERMED projects

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On the February 12th The Board of TACR approved 7 projects, which were approved by the board of the center. Namely the projects are:

  • Surface expression, function, and pharmacology of disease-associated mutations in human NMDA receptors – molecular diagnostics and drug development
  • Targeted treatment for protein mutation and aggregation diseases – tauopathies, amyloidosis and cancer
  • Targeted therapy for cells in stress – regulators of oncogenic, ribosomal and/or endoplasmatic stress response
  • Gene expression therapeutics – epigenetic and transcriptional regulators
  • Novel potent inhibitors of purine nucleoside phosphorylase for treatment of T-cell leukemia
  • Senolytics – cytotoxic therapies for aging cells
  • New human Constitutive androstane receptor (CAR, NR1I3) ligands for the treatment of metabolic diseases